Issue 1, 2009
From the journal:

Chemical Communications

Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood–brain barrier permeability for conventional therapeutics†

Zhivko Zhelev,a   Rumiana Bakalova,*a   Ichio Aoki,a   Ken-ichiro Matsumoto,b   Veselina Gadjeva,c   Kazunori Anzaib  and  Iwao Kannoa  

* Corresponding authors

a Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences (NIRS), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan
E-mail: bakalova@nirs.go.jp; ra_bakalova@yahoo.com
Fax: +81-43-206-3276
Tel: +81-43-206-4067

b Center for Heavy-ion Particle Therapy, National Institute of Radiological Sciences (NIRS), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan

c Department of Chemistry and Biochemistry, Trakia University, Stara Zagora, Bulgaria

Abstract

The present study describes a novel non-radioactive methodology for in vivo non-invasive, real-time imaging of blood–brain barrier (BBB) permeability for conventional drugs, using nitroxyl radicals as spin-labels and magnetic resonance imaging (MRI).

Graphical abstract: Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood–brain barrier permeability for conventional therapeutics

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Article information

DOI
https://doi.org/10.1039/B816878D
Article type
Communication
Submitted
26 Sep 2008
Accepted
20 Oct 2008
First published
13 Nov 2008

Chem. Commun., 2009, 53-55

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Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood–brain barrier permeability for conventional therapeutics

Z. Zhelev, R. Bakalova, I. Aoki, K. Matsumoto, V. Gadjeva, K. Anzai and I. Kanno, Chem. Commun., 2009, 53 DOI: 10.1039/B816878D

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