Issue 20, 2010

“Higher density does not mean higher stability” mystery of paracetamol finally unraveled

Abstract

Topological analysis of the experimental electron density distribution functions for two polymorphs of paracetamol showed that strong H-bonds are responsible for the higher stability of crystal phase I, weak interactions for the higher density of phase II. This made it possible to finally resolve the contradiction between the relative stabilities and the densities of the two paracetamol polymorphs.

Graphical abstract: “Higher density does not mean higher stability” mystery of paracetamol finally unraveled

Supplementary files

Article information

Article type
Communication
Submitted
05 Jan 2010
Accepted
13 Apr 2010
First published
21 Apr 2010

Chem. Commun., 2010,46, 3469-3471

“Higher density does not mean higher stability” mystery of paracetamol finally unraveled

Y. V. Nelyubina, I. V. Glukhov, M. Yu. Antipin and K. A. Lyssenko, Chem. Commun., 2010, 46, 3469 DOI: 10.1039/B927429D

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