Issue 2, 2011
From the journal:

MedChemComm

New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles†

Claude P. Gros,*a   Antoine Eggenspiller,a   Aline Nonat,a   Jean-Michel Barbea  and  Franck Denat*a  

* Corresponding authors

a Institut de Chimie Moléculaire de l'Université de Bourgogne, ICMUB, UMR 5260, 9, avenue Alain Savary BP 47870, Dijon cedex, France
E-mail: claude.gros@u-bourgogne.fr, franck.denat@u-bourgogne.fr
Fax: +33 38039 6117
Tel: +33 38039 6112/6115

Abstract

A bifunctional chelator featuring (DO3A-AM)-Porphyrin units has been prepared. The high-field relaxivity of the Gd complex is similar to those of currently available contrast agents clearly showing that the first coordination sphere remains identical to the parent molecule [Gd(DO3A-AM)(H2O)], with one coordinated water molecule.

Graphical abstract: New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles

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Article information

DOI
https://doi.org/10.1039/C0MD00205D
Article type
Concise Article
Submitted
05 Nov 2010
Accepted
14 Nov 2010
First published
06 Dec 2010

Med. Chem. Commun., 2011,2, 119-125

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New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles

C. P. Gros, A. Eggenspiller, A. Nonat, J. Barbe and F. Denat, Med. Chem. Commun., 2011, 2, 119 DOI: 10.1039/C0MD00205D

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