Issue 4, 2011
From the journal:

Organic & Biomolecular Chemistry

Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone†

Alejandro F. Barrero,*a   M. Mar Herrador,*a   José F. Quílez del Moral,a   Pilar Arteaga,a   Niklas Meine,a   M. Carmen Pérez-Moralesa  and  Julieta V. Catalána  

* Corresponding authors

a Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avda Fuente Nueva, s/n, 18071 Granada, Spain
E-mail: afbarre@ugr.es, mmar@ugr.es
Fax: +34 958243318
Tel: +34 958243318

Abstract

Highly efficient preparations of anticancer β-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3–5 steps with excellent overall yields (43–54%). An enantioselective approach to these molecules is also described

Graphical abstract: Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone

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Article information

DOI
https://doi.org/10.1039/C0OB00467G
Article type
Paper
Submitted
21 Jul 2010
Accepted
04 Nov 2010
First published
24 Dec 2010

Org. Biomol. Chem., 2011,9, 1118-1125

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Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone

A. F. Barrero, M. M. Herrador, J. F. Quílez del Moral, P. Arteaga, N. Meine, M. C. Pérez-Morales and J. V. Catalán, Org. Biomol. Chem., 2011, 9, 1118 DOI: 10.1039/C0OB00467G

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