Stereoselective synthesis of a (5R,6S)-6-[(R)-1-hydroxyethyl]-2-aryloxy penem
Abstract
(5R,6S)-[(R)-1-Hydroxyethyl]-2-aryloxypenems can be synthesized through hydroxy group directed chlorinolysis of the (3S/,4R)-3-[(R)-1-hydroxyethyl]-4-ethylthioazetidinone (8) to the (4S)-4-chloroazetidinone (9) with subsequent cyclisation.