SCHEDULED MAINTENANCE
The Wittig reaction between phosphonium salt 1 and the hydroxybutenolide 2 followed by deprotection, macrocyclisation, and reduction gives the 6-hydroxymilbemycin E 9 which by further cyclisation is converted into milbemycin G 11.
S. Bailey, A. Teerawutgulrag and E. J. Thomas, J. Chem. Soc., Chem. Commun., 1995, 2521 DOI: 10.1039/C39950002521
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