Issue 2, 2014
From the journal:

Chemical Communications

Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide†

Jason M. D. Kalapothakis,a   Yana Berezovskaya,a   Cleidiane G. Zampronio,b   Peter A. Faull,a   Perdita E. Barran*a  and  Helen J. Cooper*b  

* Corresponding authors

a School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh, UK
E-mail: perdita.barran@ed.ac.uk
Tel: +44 (0)131 650 7533

b School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: h.j.cooper@bham.ac.uk

Abstract

The helix-forming character of a model decapeptide, L4PL4K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.

Graphical abstract: Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

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Article information

DOI
https://doi.org/10.1039/C3CC46356G
Article type
Communication
Submitted
19 Aug 2013
Accepted
15 Oct 2013
First published
16 Oct 2013

Chem. Commun., 2014,50, 198-200

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Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

J. M. D. Kalapothakis, Y. Berezovskaya, C. G. Zampronio, P. A. Faull, P. E. Barran and H. J. Cooper, Chem. Commun., 2014, 50, 198 DOI: 10.1039/C3CC46356G

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