Issue 10, 2014

The synthesis and structure revision of NSC-134754

Abstract

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF.

Graphical abstract: The synthesis and structure revision of NSC-134754

Supplementary files

Article information

Article type
Communication
Submitted
28 Oct 2013
Accepted
05 Dec 2013
First published
09 Dec 2013

Chem. Commun., 2014,50, 1238-1240

The synthesis and structure revision of NSC-134754

J. A. Hickin, A. Ahmed, K. Fucke, M. Ashcroft and K. Jones, Chem. Commun., 2014, 50, 1238 DOI: 10.1039/C3CC48189A

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