Issue 6, 2015

Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies

Abstract

Phototherapies such as photodynamic therapy (PDT) and photothermal therapy (PTT), due to their specific spatiotemporal selectivity and minimal invasiveness, have been widely investigated as alternative treatments of malignant diseases. Graphene and its derivatives not only have been used as carriers to deliver photosensitizers for PDT, but also as photothermal conversion agents (PTCAs) for PTT. Herein, we strategically designed and produced a novel photo-theranostic platform based on sinoporphyrin sodium (DVDMS) photosensitizer-loaded PEGylated graphene oxide (GO-PEG-DVDMS) for enhanced fluorescence/photoacoustic (PA) dual-modal imaging and combined PDT and PTT. The GO-PEG carrier drastically improves the fluorescence of loaded DVDMS via intramolecular charge transfer. Concurrently, DVDMS significantly enhances the near-infrared (NIR) absorption of GO for improved PA imaging and PTT. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. This novel theranostics is well suited for fluorescence/PA dual-modal imaging and synergistic PDT/PTT.

Graphical abstract: Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies

Article information

Article type
Paper
Submitted
20 Nov 2014
Accepted
23 Dec 2014
First published
26 Dec 2014

Nanoscale, 2015,7, 2520-2526

Author version available

Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies

X. Yan, H. Hu, J. Lin, A. J. Jin, G. Niu, S. Zhang, P. Huang, B. Shen and X. Chen, Nanoscale, 2015, 7, 2520 DOI: 10.1039/C4NR06868H

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