Issue 102, 2014
From the journal:

RSC Advances

Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery†

E. Crucianelli,a   P. Bruni,b   A. Frontini,c   L. Massaccesi,a   M. Pisani,b   A. Smorlesic  and  G. Mobbili*a  

* Corresponding authors

a Di.S.V.A. Department, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
E-mail: g.mobbili@univpm.it

b SIMAU Department, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy

c Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Via Tronto, 60126 Ancona, Italy

Abstract

Lysosomes are promising targets for cancer and enzyme replacement therapy. In this area of interest we present a novel liposomal nanocarrier containing mannose 6-phosphate-cholesteryl conjugates and show its ability to reach the lysosomes by means of confocal and fluorescence microscopy measurements.

Graphical abstract: Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery

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Article information

DOI
https://doi.org/10.1039/C4RA08681C
Article type
Communication
Submitted
14 Aug 2014
Accepted
30 Oct 2014
First published
30 Oct 2014

RSC Adv., 2014,4, 58204-58207

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Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery

E. Crucianelli, P. Bruni, A. Frontini, L. Massaccesi, M. Pisani, A. Smorlesi and G. Mobbili, RSC Adv., 2014, 4, 58204 DOI: 10.1039/C4RA08681C

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