Issue 40, 2015
From the journal:

Chemical Communications

A luminescent cyclometalated gold(iii)–avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity†

Johnson Lui-Lui Tsai,a   Anna On-Yee Chana  and  Chi-Ming Che*ab  

* Corresponding authors

a State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Center and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk
Fax: +852-2857-1586

b HKU Shenzhen Institute of Research and Innovation, Shenzhen 518053, China

Abstract

Here we describe a luminescent cyclometalated Au(III)–avidin conjugate that exhibits a 520 nm emission with a lifetime of 1.8 μs in PBS solution in open air. The conjugate stains proteins and DNA and can inhibit cancer cell proliferation.

Graphical abstract: A luminescent cyclometalated gold(iii)–avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity

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Article information

DOI
https://doi.org/10.1039/C5CC00186B
Article type
Communication
Submitted
09 Jan 2015
Accepted
28 Mar 2015
First published
21 Apr 2015

Chem. Commun., 2015,51, 8547-8550

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A luminescent cyclometalated gold(III)–avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity

J. L. Tsai, A. O. Chan and C. Che, Chem. Commun., 2015, 51, 8547 DOI: 10.1039/C5CC00186B

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