Issue 49, 2015

A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(iii)-based i-motif probe

Abstract

An iridium(III) complex exhibiting higher responce towards i-motif DNA over dsDNA and ssDNA was employed for the construction of a TdT activity detection platform. The assay exhibited a linear signal enhancement for TdT in the concentration range of 0 to 8 U mL−1, and the limit of detection for TdT was 0.25 U mL−1.

Graphical abstract: A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(iii)-based i-motif probe

Supplementary files

Article information

Article type
Communication
Submitted
03 Apr 2015
Accepted
17 May 2015
First published
18 May 2015

Chem. Commun., 2015,51, 9953-9956

A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe

L. Lu, M. Wang, L. Liu, C. Wong, C. Leung and D. Ma, Chem. Commun., 2015, 51, 9953 DOI: 10.1039/C5CC02790J

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