A high-performance imaging probe with NIR luminescence and synergistically enhanced T1–T2 relaxivity for in vivo hepatic tumor targeting and multimodal imaging

Jian Liu; Zhengzheng Li; Xiangliang Yang; Weisheng Liu; Baodui Wang; Yanhong Zhu; Ketao Mu; Wenzhen Zhu

doi:10.1039/C5CC04911C

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A high-performance imaging probe with NIR luminescence and synergistically enhanced T₁–T₂ relaxivity for in vivo hepatic tumor targeting and multimodal imaging†

Jian Liu,‡^a Zhengzheng Li,‡^b Xiangliang Yang,^b Weisheng Liu,^a Baodui Wang,*^a Yanhong Zhu,*^b Ketao Mu^c and Wenzhen Zhu^c

Author affiliations

* Corresponding authors

^a Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry Lanzhou University Gansu, Lanzhou University, Lanzhou, P. R. China
E-mail: wangbd@lzu.edu.cn

^b College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, P. R. China
E-mail: yhzhu@mail.hust.edu.cn

^c Radiology Department of Tongji Hospital, Huazhong University of Science and Technology, Wuhan, P. R. China

Abstract

A high-performance imaging probe with NIR luminescence and synergistically enhanced T₁−T₂ relaxivity was synthesized. This nanoprobe exhibits a relatively high tumor-targeting efficacy and enables NIR optical and T₁-/T₂-weighted MR imaging of hepatic tumor cells in vivo.

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Article information

DOI: https://doi.org/10.1039/C5CC04911C
Article type: Communication
Submitted: 14 Jun 2015
Accepted: 14 Jul 2015
First published: 14 Jul 2015

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Chem. Commun., 2015,51, 13369-13372

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A high-performance imaging probe with NIR luminescence and synergistically enhanced T₁–T₂ relaxivity for in vivo hepatic tumor targeting and multimodal imaging

J. Liu, Z. Li, X. Yang, W. Liu, B. Wang, Y. Zhu, K. Mu and W. Zhu, Chem. Commun., 2015, 51, 13369 DOI: 10.1039/C5CC04911C

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Chemical Communications