Issue 95, 2015

Asymmetric bromine–lithium exchange: on the importance of both the diamine ligand and the organolithium reagent

Abstract

The asymmetric bromine–lithium exchange on a series of prochiral biphenyls was investigated. As in many asymmetric organolithium reactions, the chiral ligand (here a diamine) was considered to be the enantiocontrolling element. We show here that the organolithium reagent also plays an important role.

Graphical abstract: Asymmetric bromine–lithium exchange: on the importance of both the diamine ligand and the organolithium reagent

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2015
Accepted
29 Sep 2015
First published
29 Sep 2015

Chem. Commun., 2015,51, 16912-16915

Asymmetric bromine–lithium exchange: on the importance of both the diamine ligand and the organolithium reagent

J. Praz, J. Graff, L. Egger, L. Guénée, S. Wagschal, E. P. Kündig and A. Alexakis, Chem. Commun., 2015, 51, 16912 DOI: 10.1039/C5CC06548H

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