Issue 96, 2015
From the journal:

Chemical Communications

Protein delivery with cell-penetrating poly(disulfide)s†

Giulio Gasparinia  and  Stefan Matile*a  

* Corresponding authors

a School of Chemistry and Biochemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland
E-mail: stefan.matile@unige.ch
Web: http://www.unige.ch/sciences/chiorg/matile/
Fax: +41 22 379 5123
Tel: +41 22 379 6523

Abstract

The combination of cell-penetrating poly(disulfide)s with biotin–streptavidin biotechnology provides a simple, general, non-toxic method that avoids significant endosomal capture and delivers proteins directly, even to the nucleoli.

Graphical abstract: Protein delivery with cell-penetrating poly(disulfide)s

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Article information

DOI
https://doi.org/10.1039/C5CC07460F
Article type
Communication
Submitted
05 Sep 2015
Accepted
06 Oct 2015
First published
08 Oct 2015

Chem. Commun., 2015,51, 17160-17162

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Protein delivery with cell-penetrating poly(disulfide)s

G. Gasparini and S. Matile, Chem. Commun., 2015, 51, 17160 DOI: 10.1039/C5CC07460F

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