Issue 11, 2016

New amination strategies based on nitrogen-centered radical chemistry

Abstract

The interesting and diverse biological activities of nitrogen-containing compounds make the construction of the C–N bond of great importance. Despite the tremendous advances that have been made in this research field, C–N bond formation based on nitrogen-centered radicals remains a significant challenge due to the harsh conditions required for the generation of nitrogen-centered radicals and their propensity for hydrogen abstraction or engaging in other degradation pathways. In the past several years, novel methodologies for C–N bond constructions based on nitrogen centered-radical intermediates, coordinated with metal or generated in the presence of visible-light and a photocatalyst, have attracted considerable attention. This tutorial review will summarize the significant progress of these efficient and mild radical amination reactions, with an emphasis on approaches for the generation of nitrogen-centered radicals and their reaction patterns, related mechanisms and synthetic applications, as well as unmet challenges in this emerging and promising field.

Graphical abstract: New amination strategies based on nitrogen-centered radical chemistry

Article information

Article type
Tutorial Review
Submitted
12 Nov 2015
First published
27 Apr 2016

Chem. Soc. Rev., 2016,45, 3069-3087

New amination strategies based on nitrogen-centered radical chemistry

T. Xiong and Q. Zhang, Chem. Soc. Rev., 2016, 45, 3069 DOI: 10.1039/C5CS00852B

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