Issue 41, 2015

N-heterocyclic carbene copper(i) catalysed N-methylation of amines using CO2

Abstract

The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.

Graphical abstract: N-heterocyclic carbene copper(i) catalysed N-methylation of amines using CO2

Supplementary files

Article information

Article type
Paper
Submitted
08 Sep 2015
Accepted
23 Sep 2015
First published
30 Sep 2015
This article is Open Access
Creative Commons BY license

Dalton Trans., 2015,44, 18138-18144

N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

O. Santoro, F. Lazreg, Y. Minenkov, L. Cavallo and C. S. J. Cazin, Dalton Trans., 2015, 44, 18138 DOI: 10.1039/C5DT03506F

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