Physicochemical and antimicrobial photodynamic chemotherapy of unsymmetrical indium phthalocyanines alone or in the presence of magnetic nanoparticles

Abstract

An AB₃ type photosensitiser, consisting of 4-pyridylsulfanyl units (denoted as B₃) and one aminophenoxy (denoted as A) group (complex 3) was synthesized. Complex 3 was then quaternized to form complex 4. The aminophenoxy substituent of complex 3 was used for the formation of the amide linkage with the carboxylic functionalised magnetic nanoparticles. Complexes 3 and 4 and their conjugates with magnetic nanoparticles were then used for photodynamic antimicrobial chemotherapy on E. coli. The cationic photosensitiser 4 showed a high efficiency for photodynamic antimicrobial chemotherapy at a very low concentration compared to its conjugate on E. coli.