Issue 19, 2015

Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

Abstract

A general and efficient synthesis of trifluoromethyl substituted 5-alkylidene-1,3-dioxolane using a silver salt and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols and trifluoromethyl ketones is described. The procedure produced 5-alkylidene-1,3-dioxolane derivatives with good to excellent yields and can be used with a broad range of substrates.

Graphical abstract: Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

Supplementary files

Article information

Article type
Paper
Submitted
05 Mar 2015
Accepted
02 Apr 2015
First published
10 Apr 2015

Org. Biomol. Chem., 2015,13, 5399-5406

Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

J. Wang, W. Kong, F. Li, J. Liu, Q. Shen, L. Liu and W. Zhao, Org. Biomol. Chem., 2015, 13, 5399 DOI: 10.1039/C5OB00438A

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