An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.
S. Moon, S. Jung, U. Bin Kim and W. Kim, RSC Adv., 2015, 5, 79385 DOI: 10.1039/C5RA14890A
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