Issue 37, 2016, Issue in Progress

HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis

Abstract

Heat-stable antifungal factor (HSAF) belongs to polycyclic tetramate macrolactams (PTMs), which inhibits many fungal pathogens and is effective in inhibiting Candida albicans (C. albicans). In this study, we found that HSAF induced the apoptosis of C. albicans SC5314 through inducing the production of reactive oxygen species (ROS). Nevertheless, we validated the efficacy of HSAF against candidiasis caused by C. albicans in a murine model in vivo, and HSAF significantly improved survival and reduced fungal burden compared to vehicles. A molecular dynamics (MD) simulation was also investigated, revealing the theoretical binding mode of HSAF to the β-tubulin of C. albicans. This study first found PTMs-induced fungal apoptosis through ROS accumulation in C. albicans and its potential as a novel agent for fungicides.

Graphical abstract: HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis

Article information

Article type
Paper
Submitted
07 Dec 2015
Accepted
17 Mar 2016
First published
21 Mar 2016

RSC Adv., 2016,6, 30895-30904

Author version available

HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis

Y. Ding, Z. Li, Y. Li, C. Lu, H. Wang, Y. Shen and L. Du, RSC Adv., 2016, 6, 30895 DOI: 10.1039/C5RA26092B

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