Issue 36, 2015

Facile synthesis of N-halamine-labeled silica–polyacrylamide multilayer core–shell nanoparticles for antibacterial ability

Abstract

Silica–polymer antimicrobial composites with a core–shell nanostructure are often prepared through a polymeric process. However, it is difficult to control the polymerization degree of the polymers to give a uniform size distribution. In this article, we present a facile approach to produce antimicrobial silica@polyacrylamide (SiO2@PAM) core–shell nanoparticles, which were synthesized via an electrostatic self-assembly method using acyclic N-halamine polymeric polyacrylamide. The morphologies and structures of these as-prepared nanoparticles were characterized by different techniques. And their antibacterial performance against both Gram-positive bacteria and Gram-negative bacteria was also evaluated. Based on the preliminary results, these core–shell nanosized spheres were made of an outer polymer shell which decorated the inner SiO2 core, showing the encapsulation of silica nanoparticles with PAM polymers. After chlorination, the resultant nanosized particles displayed a powerful and stable bactericidal capability toward both of the two model bacterial species. Bactericidal assessment further suggested a coordinated effect of the well-known antibacterial performance of N-halamines and the flocculation of PAM on the antibacterial behavior. The in vitro cytotoxicity of the prepared nanoparticles with varying concentrations was studied using mouse fibroblast cells (L929). The CCK-8 assay revealed that the SiO2@PAM composites possessed a non-cytotoxic and favorable response to the seeded cells in vitro. These results indicate the suitability of the SiO2@PAM composite particles for controlling biocidal activity, demonstrating their potential applications in deactivating bacteria or even disease control.

Graphical abstract: Facile synthesis of N-halamine-labeled silica–polyacrylamide multilayer core–shell nanoparticles for antibacterial ability

Supplementary files

Article information

Article type
Paper
Submitted
21 May 2015
Accepted
06 Aug 2015
First published
07 Aug 2015

J. Mater. Chem. B, 2015,3, 7203-7212

Author version available

Facile synthesis of N-halamine-labeled silica–polyacrylamide multilayer core–shell nanoparticles for antibacterial ability

Q. Qiu, T. Liu, Z. Li and X. Ding, J. Mater. Chem. B, 2015, 3, 7203 DOI: 10.1039/C5TB00973A

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