Issue 95, 2016
From the journal:

Chemical Communications

A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium†

Herbert W. Kavunja,a   Brent F. Piligian,a   Taylor J. Fiolek,a   Hannah N. Foley,a   Temitope O. Nathana  and  Benjamin M. Swarts*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI 48859, USA
E-mail: ben.swarts@cmich.edu

Abstract

Protein O-mycoloylation is a unique post-translational lipidation that was recently discovered in Corynebacterium. We describe an alkyne-modified trehalose monomycolate chemical reporter that can metabolically tag O-mycoloylated proteins in C. glutamicum, enabling their detection and identification through click chemistry.

Graphical abstract: A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium

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Article information

DOI
https://doi.org/10.1039/C6CC07143K
Article type
Communication
Submitted
31 Aug 2016
Accepted
28 Oct 2016
First published
01 Nov 2016

Chem. Commun., 2016,52, 13795-13798

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A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium

H. W. Kavunja, B. F. Piligian, T. J. Fiolek, H. N. Foley, T. O. Nathan and B. M. Swarts, Chem. Commun., 2016, 52, 13795 DOI: 10.1039/C6CC07143K

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