A highly sensitive and selective fluorescence off–on probe for the detection of intracellular endogenous tyrosinase activity

Xiaofeng Wu; Xiaohua Li; Hongyu Li; Wen Shi; Huimin Ma

doi:10.1039/C6CC09679D

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A highly sensitive and selective fluorescence off–on probe for the detection of intracellular endogenous tyrosinase activity†

Xiaofeng Wu,^ab Xiaohua Li,

*^ab Hongyu Li,^a Wen Shi

^a and Huimin Ma*^ab

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: lixh@iccas.ac.cn, mahm@iccas.ac.cn

^b University of the Chinese Academy of Sciences, Beijing 100049, China

Abstract

A resorufin-based highly sensitive and selective fluorescence off–on probe with a new recognition moiety for tyrosinase is developed, and applied to detect and image endogenous tyrosinase activity in different living cells.

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Article information

DOI: https://doi.org/10.1039/C6CC09679D
Article type: Communication
Submitted: 06 Dec 2016
Accepted: 24 Jan 2017
First published: 24 Jan 2017

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Chem. Commun., 2017,53, 2443-2446

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A highly sensitive and selective fluorescence off–on probe for the detection of intracellular endogenous tyrosinase activity

X. Wu, X. Li, H. Li, W. Shi and H. Ma, Chem. Commun., 2017, 53, 2443 DOI: 10.1039/C6CC09679D

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Chemical Communications

A highly sensitive and selective fluorescence off–on probe for the detection of intracellular endogenous tyrosinase activity†

Abstract

Supplementary files

Article information

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A highly sensitive and selective fluorescence off–on probe for the detection of intracellular endogenous tyrosinase activity

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