Issue 16, 2016
From the journal:

Green Chemistry

Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams†

Eleonora Fava,ab   Masaki Nakajima,a   Martin B. Tabaka  and  Magnus Rueping*ab  

* Corresponding authors

a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen, Germany
E-mail: Magnus.Rueping@rwth-aachen.de
Tel: +49-241-8094686

b King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC), Thuwal, Saudi Arabia

Abstract

The first visible light mediated tin-free cyclisation of α-chloroenamides leading to the synthesis of substituted γ-lactams with excellent stereoselectivity is reported. The protocol employs the single-electron reduction of activated C–Cl bonds, which are typically inert towards reduction.

Graphical abstract: Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

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Article information

DOI
https://doi.org/10.1039/C6GC01099G
Article type
Communication
Submitted
18 Apr 2016
Accepted
24 Jun 2016
First published
13 Jul 2016
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2016,18, 4531-4535

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Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

E. Fava, M. Nakajima, M. B. Tabak and M. Rueping, Green Chem., 2016, 18, 4531 DOI: 10.1039/C6GC01099G

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