A MnO2 nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

Zhen-Zhen Dong; Lihua Lu; Chung-Nga Ko; Chao Yang; Shengnan Li; Ming-Yuen Lee; Chung-Hang Leung; Dik-Lung Ma

doi:10.1039/C6NR08357A

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A MnO₂ nanosheet-assisted GSH detection platform using an iridium(iii) complex as a switch-on luminescent probe†

Zhen-Zhen Dong,‡^a Lihua Lu,‡^ab Chung-Nga Ko,‡^a Chao Yang,‡^c Shengnan Li,^c Ming-Yuen Lee,^c Chung-Hang Leung*^c and Dik-Lung Ma

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk

^b College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China

^c State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
E-mail: duncanleung@umac.mo

Abstract

A rapid and sensitive detection platform for GSH has been constructed by combining a MnO₂ nanosheet with a luminescent iridium(III) complex [Ir(Cl-phq)₂(Cl-phen)]⁺. The MnO₂ nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 μM (R² = 0.9951), and the detection limit for GSH was 0.13 μM. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.

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Article information

DOI: https://doi.org/10.1039/C6NR08357A
Article type: Paper
Submitted: 25 Oct 2016
Accepted: 12 Jan 2017
First published: 13 Jan 2017

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Nanoscale, 2017,9, 4677-4682

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A MnO₂ nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

Z. Dong, L. Lu, C. Ko, C. Yang, S. Li, M. Lee, C. Leung and D. Ma, Nanoscale, 2017, 9, 4677 DOI: 10.1039/C6NR08357A

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