Issue 51, 2016, Issue in Progress

Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics

Abstract

For better tissue regeneration, the combination of beneficial inorganic ions may provide a more effective and safer strategy to couple with multi-functions (such as osteogenesis, angiogenesis and antibacterial activity) as compared with growth factors. Previous studies have demonstrated that Si ions released from silicate bioceramics could promote osteogenesis and angiogenesis. Divalent copper ions (Cu2+) were widely reported to enhance angiogenesis and possess antibacterial activity. Therefore, we hypothesize that the combination of Cu and Si ions may reveal better osteogenic, angiogenic and antibacterial activity. In this study, we synthesized a Cu-containing silicate bioceramic, cuprorivaite (CaCuSi4O10, Cup) and investigated its in vitro osteogenic, angiogenic and antibacterial capacities. We, for the first time, successfully synthesized Cup powders with high-purity by sol–gel method. In vitro biological evaluation indicated that ionic dissolution products of Cup ceramics in the concentration range of 0.195–0.78 mg mL−1 were able to significantly promote angiogenesis. More importantly, Si and Cu ions had a synergistic effect on angiogenesis at lower concentrations compared with those reported in the literature. Moreover, Cup ceramics had good antibacterial activity. However, ionic dissolution products of Cup ceramics at 0.195–0.78 mg mL−1 notably suppressed ALP activity of osteoblast-like cells. Therefore, Cup bioceramics may have a potential application in wound healing, but may not be suitable for bone regeneration.

Graphical abstract: Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics

Article information

Article type
Paper
Submitted
30 Mar 2016
Accepted
02 May 2016
First published
04 May 2016

RSC Adv., 2016,6, 45840-45849

Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics

T. Tian, C. Wu and J. Chang, RSC Adv., 2016, 6, 45840 DOI: 10.1039/C6RA08145B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements