Issue 30, 2017

Ru(ii)-(PTA) and -mPTA complexes with N2-donor ligands bipyridyl and phenanthroline and their antiproliferative activities on human multiple myeloma cell lines

Abstract

A series of novel ruthenium(II) 2,2′-bipyridyl (bpy) and 1,10-phenanthroline (phen) derivatives containing PTA (1,3,5-triaza-7-phosphaadamantane) or mPTA (N-methyl-1,3,5-triaza-7-phosphaadamantane cation) have been synthesized and fully characterized. Three types of complexes have been obtained, neutral [Ru(N–N)(PTA)2Cl2] (1, N–N = bpy and 4, N–N = phen), monocationic [Ru(N–N)(PTA)3Cl][Cl] (2, N–N = bpy and 5, N–N = phen) and dicationic [Ru(N–N)(mPTA)Cl2][BF4]2 (3, N–N = bpy and 6, N–N = phen). The solid-state structures of four complexes have been determined by single-crystal X-ray diffraction. The cytotoxicity of the complexes has been evaluated in vitro against U266 and RPMI human multiple myeloma cells.

Graphical abstract: Ru(ii)-(PTA) and -mPTA complexes with N2-donor ligands bipyridyl and phenanthroline and their antiproliferative activities on human multiple myeloma cell lines

Supplementary files

Article information

Article type
Paper
Submitted
05 Jun 2017
Accepted
04 Jul 2017
First published
07 Jul 2017
This article is Open Access
Creative Commons BY license

Dalton Trans., 2017,46, 10073-10081

Ru(II)-(PTA) and -mPTA complexes with N2-donor ligands bipyridyl and phenanthroline and their antiproliferative activities on human multiple myeloma cell lines

A. Wołoszyn, C. Pettinari, R. Pettinari, G. V. Badillo Patzmay, A. Kwiecień, G. Lupidi, M. Nabissi, G. Santoni and P. Smoleński, Dalton Trans., 2017, 46, 10073 DOI: 10.1039/C7DT02051A

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