Issue 10, 2017

The transferrin receptor: the cellular iron gate

Abstract

The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels. In this review, we have discussed the latest advances in the molecular regulation of TfR1 expression and we have considered current understanding of TfR1 function beyond its canonical role in providing iron for erythroid precursors and rapidly proliferating cells.

Graphical abstract: The transferrin receptor: the cellular iron gate

Article information

Article type
Critical Review
Submitted
02 May 2017
Accepted
13 Jun 2017
First published
13 Jun 2017

Metallomics, 2017,9, 1367-1375

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