Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

Chiara Mauriello-Jimenez; Maxime Henry; Dina Aggad; Laurence Raehm; Xavier Cattoën; Michel Wong Chi Man; Clarence Charnay; Serkan Alpugan; Vefa Ahsen; Deniz Kutlu Tarakci; Philippe Maillard; Marie Maynadier; Marcel Garcia; Fabienne Dumoulin; Magali Gary-Bobo; Jean-Luc Coll; Véronique Josserand; Jean-Olivier Durand

doi:10.1039/C7NR04677D

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging†

Chiara Mauriello-Jimenez,‡^a Maxime Henry,‡^bc Dina Aggad,^d Laurence Raehm,^a Xavier Cattoën,^e Michel Wong Chi Man,^a Clarence Charnay,^a Serkan Alpugan,^f Vefa Ahsen,

^f Deniz Kutlu Tarakci,^f Philippe Maillard,^g Marie Maynadier,^h Marcel Garcia,^d Fabienne Dumoulin,

*^f Magali Gary-Bobo,*^d Jean-Luc Coll,^bc Véronique Josserand*^bc and Jean-Olivier Durand

*^a

Author affiliations

* Corresponding authors

^a Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM, cc 1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France
E-mail: durand@univ-montp2.fr

^b INSERM U1209, Institute for Advanced Biosciences, F-38000 Grenoble, France

^c Univ. Grenoble Alpes, Institute for Advanced Biosciences, F-38000 Grenoble, France
E-mail: veronique.josserand@univ-grenoble-alpes.fr

^d Institut de Biomolécules Max Mousseron, UMR 5247, Université de Montpellier, Avenue Charles Flahault, 34093 Montpellier Cedex 05, France
E-mail: magali.gary-bobo@inserm.tr

^e Institut NEEL CNRS/UGA UPR2940, 25 rue des Martyrs BP 166, 38042 Grenoble edex 9, France

^f Gebze Technical University, Department of Chemistry, Gebze 41400 Kocaeli, Turkey
E-mail: fdumoulin@gtu.edu.tr

^g Unité CMIB, UMR 9187 CNRS – U1196 INSERM, Institut CURIE-Recherche Bât. 110-112, Rue H. Becquerel, Centre Universitaire, F-91 405 Orsay, France

^h NanoMedSyn, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05, France

Abstract

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.

Nanoscale

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging†

Abstract

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Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

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