Issue 5, 2017

Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese–PNN pincer complex

Abstract

Novel well-defined NNP and PNP manganese pincer complexes have been synthetized and fully characterized. The catalyst Mn-2 containing an imidazolyaminolphosphino ligand shows high activity and selectivity in the hydrogenation of a wide range of secondary and tertiary amides to the corresponding alcohols and amines, under relatively mild conditions. For the first time, more challenging substrates like primary aromatic amides including an actual herbicide can also be hydrogenated using this earth-abundant metal-based pincer catalyst.

Graphical abstract: Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese–PNN pincer complex

Supplementary files

Article information

Article type
Edge Article
Submitted
11 Jan 2017
Accepted
24 Feb 2017
First published
08 Mar 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 3576-3585

Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese–PNN pincer complex

V. Papa, J. R. Cabrero-Antonino, E. Alberico, A. Spanneberg, K. Junge, H. Junge and M. Beller, Chem. Sci., 2017, 8, 3576 DOI: 10.1039/C7SC00138J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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