Issue 4, 2019

La-Doped mesoporous calcium silicate/chitosan scaffolds for bone tissue engineering

Abstract

Trace rare earth elements such as lanthanum (La) regulated effectively bone tissue performances; however, the underlying mechanism remains unknown. In order to accelerate bone defects especially in patients with osteoporosis or other metabolic diseases, we firstly constructed lanthanum-doped mesoporous calcium silicate/chitosan (La-MCS/CTS) scaffolds by freeze-drying technology. During the freeze-drying procedure, three-dimensional macropores were produced within the La-MCS/CTS scaffolds by using ice crystals as templates, and the La-MCS nanoparticles were distributed on the macropore walls. The hierarchically porous structures and biocompatible components contributed to the adhesion, spreading and proliferation of rat bone marrow-derived mesenchymal stem cells (rBMSCs), and accelerated the in-growth of new bone tissues. Particularly, the La3+ ions in the bone scaffolds remarkably induced the osteogenic differentiation of rBMSCs via the activation of the TGF signal pathway. A critical-sized calvarial-defect rat model further revealed that the La-MCS/CTS scaffolds significantly promoted new bone regeneration as compared with pure MCS/CTS scaffolds. In conclusion, the La-MCS/CTS scaffold showed the prominent ability in osteogenesis and bone regeneration, which showed its application potential for bone defect therapy.

Graphical abstract: La-Doped mesoporous calcium silicate/chitosan scaffolds for bone tissue engineering

Supplementary files

Article information

Article type
Paper
Submitted
17 Nov 2018
Accepted
13 Jan 2019
First published
28 Jan 2019
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2019,7, 1565-1573

La-Doped mesoporous calcium silicate/chitosan scaffolds for bone tissue engineering

X. Peng, M. Hu, F. Liao, F. Yang, Q. Ke, Y. Guo and Z. Zhu, Biomater. Sci., 2019, 7, 1565 DOI: 10.1039/C8BM01498A

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