Issue 31, 2018
From the journal:

Chemical Communications

A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells†

Changyu Zhang,‡a   Qichang Nie, ORCID logo ‡b   Ismail Ismail,c   Zhen Xi*c  and  Long Yi ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Organic–Inorganic Composites and Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China
E-mail: yilong@mail.buct.edu.cn

b State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China

c State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, National Pesticide Engineering Research Center (Tianjin), Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, China
E-mail: zhenxi@nankai.edu.cn

Abstract

A new fluorescence probe was developed for HClO detection under physiological conditions, which displayed fast response (t1/2 < 30 s) and large off–on fluorescence increase (>1000-fold) toward HClO with high sensitivity and selectivity. The probe was successfully applied for the detection of both exogenous and endogenous HClO in living cells. Using the probe-based tool, we could observe the H2S-induced HClO biogenesis in living cells for the first time.

Graphical abstract: A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells

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Article information

DOI
https://doi.org/10.1039/C8CC01917G
Article type
Communication
Submitted
12 Mar 2018
Accepted
14 Mar 2018
First published
15 Mar 2018

Chem. Commun., 2018,54, 3835-3838

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A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells

C. Zhang, Q. Nie, I. Ismail, Z. Xi and L. Yi, Chem. Commun., 2018, 54, 3835 DOI: 10.1039/C8CC01917G

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