Issue 39, 2018

Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

Abstract

Here we report the design of membrane-active peptidomimetic molecules with a tunable arrangement of hydrophobic and polar groups. In spite of having the same chemical composition, the effective hydrophobicities of the compounds were different as a consequence of their chemical structure and conformational properties. The compound with lower effective hydrophobicity demonstrated antibacterial activity that was highly selective towards bacteria over mammalian cells. This study, highlighting the role in membrane selectivity of the specific arrangement of the different moieties in the molecular structure, provides useful indications for developing non-toxic antibacterial agents.

Graphical abstract: Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

Supplementary files

Article information

Article type
Communication
Submitted
09 Mar 2018
Accepted
17 Apr 2018
First published
18 Apr 2018

Chem. Commun., 2018,54, 4943-4946

Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

M. M. Konai, S. Samaddar, G. Bocchinfuso, V. Santucci, L. Stella and J. Haldar, Chem. Commun., 2018, 54, 4943 DOI: 10.1039/C8CC01926F

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