Issue 43, 2018

hIAPP forms toxic oligomers in plasma

Abstract

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

Graphical abstract: hIAPP forms toxic oligomers in plasma

Supplementary files

Article information

Article type
Communication
Submitted
17 Apr 2018
Accepted
30 Apr 2018
First published
30 Apr 2018

Chem. Commun., 2018,54, 5426-5429

hIAPP forms toxic oligomers in plasma

D. C. Rodriguez Camargo, D. Garg, K. Buday, A. Franko, A. Rodriguez Camargo, F. Schmidt, S. J. Cox, S. Suladze, M. Haslbeck, Y. G. Mideksa, G. Gemmecker, M. Aichler, G. Mettenleiter, M. Schulz, A. K. Walch, M. Hrabě de Angelis, M. J. Feige, C. A. Sierra, M. Conrad, K. Tripsianes, A. Ramamoorthy and B. Reif, Chem. Commun., 2018, 54, 5426 DOI: 10.1039/C8CC03097A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements