Issue 86, 2018

CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Abstract

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

Graphical abstract: CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
20 Jul 2018
Accepted
17 Sep 2018
First published
12 Oct 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 12234-12237

CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

E. S. Hems, B. A. Wagstaff, G. Saalbach and R. A. Field, Chem. Commun., 2018, 54, 12234 DOI: 10.1039/C8CC05113E

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