Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer

Xianshuo Zhang; Xiaolong Zhang; Lu Sun; Fangjun Liu; Mingqi Wang; Jinlei Peng; Yunfei Wang; Liwei Ma; Baoyan Wang; Hua Wei

doi:10.1039/C8CC06685J

Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer†

Xianshuo Zhang,^a Xiaolong Zhang,^a Lu Sun,^a Fangjun Liu,^a Mingqi Wang,^a Jinlei Peng,^a Yunfei Wang,^a Liwei Ma,^a Baoyan Wang^a and Hua Wei

*^a

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^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China
E-mail: weih@lzu.edu.cn

Abstract

We report in this communication the first preparation of triblock copolymer-based biocleavable shell cross-linked (SCL) hybrid micelles using a reducible silica monomer that integrates a polymerizable methacrylate structure and in situ cross-linkers of silica precursors via a disulfide bond. The monomer developed herein offers a highly straightforward and robust strategy toward bioreducible silica-based hybrid nanoparticles for controlled drug release.

Chemical Communications

Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer†

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