Issue 96, 2018

Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

Abstract

Numerous excellent fluorogenic probes for NO detection based on NO-mediated reactions have been developed. However, some of them still suffer from limitations such as low selectivity, slow response, and a short excitation wavelength (<500 nm). Herein, a novel two-photon fluorogenic probe (XNO1) based on a Schiff base derivative has been reported for the first time. This new mechanism with a Schiff base structure as the specific response moiety towards NO endows the probe with fast responsibility, high selectivity and pH-independent properties. Furthermore, XNO1 has been demonstrated to be lysosome-targeted and to successfully monitor exogenous/endogenous NO in living cells and zebrafishes with one- and two-photon fluorescence imaging.

Graphical abstract: Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

Supplementary files

Article information

Article type
Communication
Submitted
17 Aug 2018
Accepted
13 Oct 2018
First published
16 Oct 2018

Chem. Commun., 2018,54, 13491-13494

Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

C. Xu, C. Xin, C. Yu, M. Wu, J. Xu, W. Qin, Y. Ding, X. Wang, L. Li and W. Huang, Chem. Commun., 2018, 54, 13491 DOI: 10.1039/C8CC06698A

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