Selectively light-up hydrogen peroxide in hypoxic cancer cells with a novel fluorescent probe

Jianguo Wang; Wenping Zhu; Guangle Niu; Guoyu Jiang; Qingqing Chen; Pei Gao; Yongdong Li; Guanxin Zhang; Xiaolin Fan; Ben Zhong Tang

doi:10.1039/C8CC07771A

Selectively light-up hydrogen peroxide in hypoxic cancer cells with a novel fluorescent probe†

Jianguo Wang,

‡^a Wenping Zhu,‡^a Guangle Niu,

‡^b Guoyu Jiang,

*^a Qingqing Chen,^a Pei Gao,^a Yongdong Li,^a Guanxin Zhang,^c Xiaolin Fan^a and Ben Zhong Tang*^b

Author affiliations

* Corresponding authors

^a Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, P. R. China
E-mail: jiangguoyu@mail.ipc.ac.cn

^b Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

^c Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

Abstract

A novel fluorescent turn-on probe (HCyHP) was developed in a simple two-step synthesis for monitoring of exogenous and endogenous H₂O₂ levels in biological samples and hypoxic cancer diagnosis.

Chemical Communications

Selectively light-up hydrogen peroxide in hypoxic cancer cells with a novel fluorescent probe†

Abstract

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Selectively light-up hydrogen peroxide in hypoxic cancer cells with a novel fluorescent probe

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