Issue 5, 2019

ZIF nano-dagger coated gauze for antibiotic-free wound dressing

Abstract

Nano-dagger coated gauze was bactericidal against both Gram-positive and Gram-negative bacteria, with log reduction >7 for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available Ag gauze, the ZIF-L nano-dagger coated gauze was more biocompatible with a lower haemolytic activity, less cytotoxicity and improved wound healing performance. Animal studies showed that the ZIF-L coated gauze can effectively kill bacteria in a S. aureus wound infection model in mice. This novel nano-dagger coated gauze offers an effective and safe alternative for patients to protect against wound infections. This study demonstrates the first application of a MOF coating as an antibiotic-free wound dressing with potent antimicrobial activity and improved biocompatibility.

Graphical abstract: ZIF nano-dagger coated gauze for antibiotic-free wound dressing

Supplementary files

Article information

Article type
Communication
Submitted
26 Oct 2018
Accepted
10 Dec 2018
First published
11 Dec 2018

Chem. Commun., 2019,55, 699-702

ZIF nano-dagger coated gauze for antibiotic-free wound dressing

Y. Yuan, H. Wu, H. Lu, Y. Zheng, J. Y. Ying and Y. Zhang, Chem. Commun., 2019, 55, 699 DOI: 10.1039/C8CC08568D

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