Issue 4, 2019

Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel

Abstract

Based on the scaffold of astemizole, three novel turn-on fluorescent probes (N1N3) for human ether-a-go-go-related gene (hERG) potassium channel were developed herein. These probes have reasonable fluorescence properties, acceptable cell toxicity, and potent inhibitory activity, all of which contribute to cell imaging at the nanomolar level. Overall, these probes have the potential for setting up a screening system for hERG channels.

Graphical abstract: Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel

Supplementary files

Article information

Article type
Research Article
Submitted
14 Nov 2018
Accepted
25 Feb 2019
First published
26 Feb 2019

Med. Chem. Commun., 2019,10, 513-516

Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel

X. Zhang, T. Liu, B. Wang, Y. Gao, P. Liu, M. Li and L. Du, Med. Chem. Commun., 2019, 10, 513 DOI: 10.1039/C8MD00562A

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