A supramolecular hybrid material constructed from graphene oxide and a pillar[6]arene-based host–guest complex as an ultrasound and photoacoustic signal nanoamplifier

Guocan Yu; Jie Yang; Xiao Fu; Zhantong Wang; Li Shao; Zhengwei Mao; Yijing Liu; Zhen Yang; Fuwu Zhang; Wenpei Fan; Jibin Song; Zijian Zhou; Changyou Gao; Feihe Huang; Xiaoyuan Chen

doi:10.1039/C8MH00128F

A supramolecular hybrid material constructed from graphene oxide and a pillar[6]arene-based host–guest complex as an ultrasound and photoacoustic signal nanoamplifier†

Guocan Yu,‡^a Jie Yang,

‡^b Xiao Fu,‡^a Zhantong Wang,^a Li Shao,^b Zhengwei Mao,*^c Yijing Liu,^a Zhen Yang,^a Fuwu Zhang,^a Wenpei Fan,^a Jibin Song,

^a Zijian Zhou,^a Changyou Gao,^c Feihe Huang

*^b and Xiaoyuan Chen

*^a

Author affiliations

* Corresponding authors

^a Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
E-mail: shawn.chen@nih.gov

^b State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: fhuang@zju.edu.cn

^c MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: zwmao@zju.edu.cn

Abstract

Photoacoustic imaging combines the merits of ultrasound imaging and optical imaging, and allows a fascinating imaging paradigm with deeper tissue penetration than optical imaging and higher spatial resolution than ultrasound imaging. Herein, we develop a supramolecular hybrid material composed of graphene oxide (GO) and a pillar[6]arene-based host–guest complex (CP6⊃PyN), which can be used as an ultrasound (US) and photoacoustic (PA) signal nanoamplifier. Triggered by the near-infrared (NIR) light mediated photothermal effect, CO₂ nanobubbles are generated on the surface of GO@CP6⊃PyN due to the decomposition of the bicarbonate counterions, thus strongly amplifying its US and PA performances. Our study, for the first time, demonstrates enhanced US and PA activity in a supramolecular hybrid material on the basis of host–guest chemistry as a photoacoustic nanoplatform.

Materials Horizons

A supramolecular hybrid material constructed from graphene oxide and a pillar[6]arene-based host–guest complex as an ultrasound and photoacoustic signal nanoamplifier†

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A supramolecular hybrid material constructed from graphene oxide and a pillar[6]arene-based host–guest complex as an ultrasound and photoacoustic signal nanoamplifier

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