Issue 10, 2018

Protein–protein interactions in “cis-AT” polyketide synthases

Abstract

Covering: up to the end of 2018

Polyketides are a valuable source of bioactive and clinically important molecules. The biosynthesis of these chemically complex molecules has led to the discovery of equally complex polyketide synthase (PKS) pathways. Crystallography has yielded snapshots of individual catalytic domains, di-domains, and multi-domains from a variety of PKS megasynthases, and cryo-EM studies have provided initial views of a PKS module in a series of defined biochemical states. Here, we review the structural and biochemical results that shed light on the protein–protein interactions critical to catalysis by PKS systems with an embedded acyltransferase. Interactions include those that occur both within and between PKS modules, as well as with accessory enzymes.

Graphical abstract: Protein–protein interactions in “cis-AT” polyketide synthases

Article information

Article type
Review Article
Submitted
02 Jul 2018
First published
06 Sep 2018

Nat. Prod. Rep., 2018,35, 1082-1096

Protein–protein interactions in “cis-AT” polyketide synthases

G. J. Dodge, F. P. Maloney and J. L. Smith, Nat. Prod. Rep., 2018, 35, 1082 DOI: 10.1039/C8NP00058A

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