Issue 22, 2018

A catalyst-controlled switchable reaction of β-keto acids to silyl glyoxylates

Abstract

A catalyst-controlled switchable reaction of β-keto acids to silyl glyoxylates was developed under mild conditions, providing two distinct products in good yields. Compared to decarboxylative addition-Brook rearrangement, the decarboxylative addition products could be controlled by using a simple bifunctional organocatalyst thiourea derivative instead of DABCO. This new reaction model of silyl glyoxylates offered a facile and alternative route to organosilicon compounds.

Graphical abstract: A catalyst-controlled switchable reaction of β-keto acids to silyl glyoxylates

Supplementary files

Article information

Article type
Paper
Submitted
29 Mar 2018
Accepted
10 May 2018
First published
10 May 2018

Org. Biomol. Chem., 2018,16, 4117-4126

A catalyst-controlled switchable reaction of β-keto acids to silyl glyoxylates

M. Han, H. Pan, J. Lin, W. Li, P. Li and L. Wang, Org. Biomol. Chem., 2018, 16, 4117 DOI: 10.1039/C8OB00740C

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