Issue 38, 2018

A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

Abstract

A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.

Graphical abstract: A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

Supplementary files

Article information

Article type
Communication
Submitted
21 Jun 2018
Accepted
24 Jul 2018
First published
24 Jul 2018

Org. Biomol. Chem., 2018,16, 6853-6859

A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

G. Ieronimo, G. Palmisano, A. Maspero, A. Marzorati, L. Scapinello, N. Masciocchi, G. Cravotto, A. Barge, M. Simonetti, K. L. Ameta, K. M. Nicholas and A. Penoni, Org. Biomol. Chem., 2018, 16, 6853 DOI: 10.1039/C8OB01471J

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