Issue 45, 2018

Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

Abstract

A highly enantioselective nucleophilic addition of ketones to imines catalyzed by chiral phase-transfer catalysts (N-quaternised cinchona alkaloid ammonium salts) has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields (up to 95%) with excellent enantioselectivities (up to 97% ee).

Graphical abstract: Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

Supplementary files

Article information

Article type
Communication
Submitted
06 Oct 2018
Accepted
31 Oct 2018
First published
01 Nov 2018

Org. Biomol. Chem., 2018,16, 8704-8709

Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

W. Li, Y. Wang and D. Xu, Org. Biomol. Chem., 2018, 16, 8704 DOI: 10.1039/C8OB02484G

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