Issue 11, 2018

Combination of PDT photosensitizers with NO photodononors

Abstract

Combination of photodynamic therapy (PDT) with other treatment modalities is emerging as one of the most suitable strategies to increase the effectiveness of therapeutic action on cancer and bacterial diseases and to minimize side effects. This approach aims at exploiting the additive/synergistic effects arising from multiple therapeutic species acting on different mechanistic pathways. The coupling of PDT with photocontrolled release of nitric oxide (NO) through the appropriate assembly of PDT photosensitizers (PSs) and NO photodonors (NOPDs) may open up intriguing avenues towards new and still underexplored multimodal therapies not based on “conventional” drugs but entirely controlled by light stimuli. In this contribution, we present an overview of the most recent advances in this field, illustrating several strategies to assemble PSs and NOPDs allowing them to operate independently without reciprocal interferences and describing the potential applications with particular emphasis on their impact in anticancer and antibacterial research.

Graphical abstract: Combination of PDT photosensitizers with NO photodononors

Article information

Article type
Perspective
Submitted
28 Jun 2018
Accepted
07 Aug 2018
First published
13 Aug 2018

Photochem. Photobiol. Sci., 2018,17, 1709-1727

Combination of PDT photosensitizers with NO photodononors

A. Fraix and S. Sortino, Photochem. Photobiol. Sci., 2018, 17, 1709 DOI: 10.1039/C8PP00272J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements