Issue 11, 2018

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

Abstract

The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area.

Graphical abstract: Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

Article information

Article type
Perspective
Submitted
06 Aug 2018
Accepted
05 Oct 2018
First published
08 Oct 2018
This article is Open Access
Creative Commons BY-NC license

Photochem. Photobiol. Sci., 2018,17, 1553-1572

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

K. M. Tewari and I. M. Eggleston, Photochem. Photobiol. Sci., 2018, 17, 1553 DOI: 10.1039/C8PP00362A

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