Issue 3, 2019

Logical design and application of prodrug platforms

Abstract

Accurate design and high drug-loading content are the two key points in designing high-performance cancer nanomedicines. Using common strategies for drug delivery systems (DDS), such as nanoparticle (NP)-mediated DDS, lipid nanocarrier-mediated DDS, and micelle-mediated DDS, it is difficult to meet the requirements for their translation into clinical applications because of the imprecise control of the conjugation sites and density. Using drug molecules to directly construct the delivery platform is a promising approach to precisely control the composition and molecular structure. The polyprodrug platform for disease treatment is an advanced strategy with a precise structure and a high drug-loading rate. This review summarizes the current state of prodrugs, especially the polyprodrug platform, and focuses on the logical design for clinical use and proposes some practical prospects for the future development of the prodrug platform.

Graphical abstract: Logical design and application of prodrug platforms

Article information

Article type
Review Article
Submitted
08 Aug 2018
Accepted
12 Nov 2018
First published
12 Nov 2018

Polym. Chem., 2019,10, 306-324

Logical design and application of prodrug platforms

Q. Meng, H. Hu, L. Zhou, Y. Zhang, B. Yu, Y. Shen and H. Cong, Polym. Chem., 2019, 10, 306 DOI: 10.1039/C8PY01160E

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