Issue 10, 2019

A quadruple-channel fluorescent sensor array based on label-free carbon dots for sensitive detection of tetracyclines

Abstract

A quadruple-channel fluorescent sensor array based on label-free carbon dots (CDs) was fabricated to detect and discriminate a series of tetracyclines (TCs), including chlortetracycline (CTC), oxytetracycline (OTC), tetracycline (TC) and doxycycline (DOX). Blue-emitting carbon dots (B-CDs) and green-emitting carbon dots (G-CDs) were prepared to serve as four sensing elements. When the TCs were directly mixed with CDs, the fluorescence quenching phenomenon appeared. Since different TCs exhibited different affinities for sensing elements, the sensor array displays a distinct fluorescence pattern of the fluorescence intensity variation (F0 − F)/F0 for each of these TCs, which is further analyzed by principal component analysis (PCA). The present fluorescent sensor array has the capacity to differentiate TCs at a low concentration of 1 μM. Meanwhile, quantitative detection with a lower limit (0.30 μM) for TCs could be achieved by applying a single element. Moreover, a high accuracy (100%) examination of unknown samples is acquired. Finally, the fluorescent sensor array performs well in distinguishing binary mixtures and could also recognize TCs in milk.

Graphical abstract: A quadruple-channel fluorescent sensor array based on label-free carbon dots for sensitive detection of tetracyclines

Supplementary files

Article information

Article type
Paper
Submitted
22 Jan 2019
Accepted
29 Mar 2019
First published
01 Apr 2019

Analyst, 2019,144, 3307-3313

A quadruple-channel fluorescent sensor array based on label-free carbon dots for sensitive detection of tetracyclines

D. Long, J. Peng, H. Peng, H. Xian, S. Li, X. Wang, J. Chen, Z. Zhang and R. Ni, Analyst, 2019, 144, 3307 DOI: 10.1039/C9AN00148D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements